Dr. Ivan Ibañez | 4th International Congress of Integrative Medicine
ICIM 2023...
Presencial

Dr. Ivan Ibañez

Anti-Aging Medicine

Abstract

Clinical Preconditioning for StemCells

In tissue transplants and in particular autologous stem cells, one of the main
problems is the poor capacity to survive of the transplanted cells due the change in environment of unusual place. In addition, the final implantation zone is an altered tissue with low blood flow, oxygen and nutrients. On the other hand, the concept of hormesis refers to the beneficial adaptations that living beings have to make in order to survive in terms of harmful situation. Many studies have been shown a “hormetic effect” of our cells; a low stimulation dosis could have a beneficial effect, and a high dose causes inhibitory or toxic effect.

Preconditioning is an emerging therapeutic strategy that consists of small dosis of harmful agent that the body can accept (hormetic doses) that prepares us to be able to withstand more serious situations by creating more resistant organisms. Vaccins, physical exercise, intermittent fasting, intermittent hypoxiahyperoxia are some examples.

Using this concept, we have created a preconditioning program for patients who are candidates for stem cells transplantation, with that, the stem cells are more resistant in different environments and with nutrient deficiency, so we can increase their survival and improve the viability and efficiency of the stem cells therapy.

Lately, a prescription of senolytic supplement has been incorporated into
preconditioning to reduce the number of senescent stem cells.

Bibliography
Preconditioning Strategy in Stem Cell Transplantation Therapy Shan Ping Yu1, Zheng Wei1, and Ling Wei1,2, Transl Stroke Res. 2013 February ; 4(1): 7688

Hypoxia is essential for bonetendon junction healing: the molecular biological
evidence.Zhao J, Zhang P, Qin L, Pan XH. Int Orthop. 2010 Dec 3. [Epub ahead of print]

Ischaemic and hypoxic conditioning: potential for protection of vital organs. Sprick JD, Mallet RT, Przyklenk K, Rickards CA.Exp Physiol. 2019 Mar;104(3):278294. doi: 10.1113/EP087122. Epub 2019 Jan 24.

Effectiveness of three short intermittent hypobaric hypoxia protocols:
Hematological responses.Casas H, Casas M, Ricart A, Rama R, Ibáñez J, Palacios L, Rodríguez FA, Ventura JL, Viscor G, Pagès T (2000) Journal of Exercise Physiology Online, Vol. 3(2), April 2000 [http://www.css.edu/users/tboone2/asep/JEPCasa.html].

Intermittent hypobaric hypoxia stimulates erythropoiesis and improves aerobic capacity.Rodríguez FA, Casas H, Casas M, Pagès T, Rama R, Ricart A, Ventura JL, Ibáñez J, Viscor G (1999) Medicine and Science in Sports and Exercise 31(2): 264268.

L’exposition intermittente à l’hypoxie en caisson hypobarique : Effets
physiologiques et applications Ibáñez J, Casas H, Casas M, Rama R, Ricart R, Ventura J.L, Palacios L, Pages T, Rodriguez FA, Viscor G. (2000). Médecine du Sport 74(2): 3234

The potential of Senolytics in transplantation.
Matsunaga T, Iske J, Schroeter A, Azuma H, Zhou H, Tullius SG.Mech Ageing Dev. 2021 Dec;200:111582. doi: 10.1016/j.mad.2021.111582. Epub 2021 Oct 1.

Senolytics prevent mtDNAinduced inflammation and promote the survival of aged organs following transplantation.
Iske J, Seyda M, Heinbokel T, Maenosono R, Minami K, Nian Y, Quante M, Falk CS, Azuma H, Martin F, Passos JF, Niemann CU, Tchkonia T, Kirkland JL, Elkhal A, Tullius SG.Nat Commun. 2020 Aug 27;11(1):4289. doi: 10.1038/s4146702018039

CV Resumido

– Graduated as Medical Doctor (University Autonoma of Barcelona) 2003.
– Specialist in AntiAging Medicine (University of Charleroi, Belgium).
– Graduated in Advanced Studies (Dpt. of Physiology, Barcelona University).
– Master in Experimental Biology (University of Barcelona).
– Master in Physical Exercise and Rehabilitation (University of Canarias).
– President of ESCAR “European Society of Calorimetry & Respirometry”.
– Certificated for ISSCA “International Society for Stem Cells Application”.
– Medical director of CardioSport “Cardiometabolic & Longevity Medicine”.
– Responsible of Nutritional & Longevity Medicine Clínica Planas, Barcelona.
– Prof. & Director of AntiAging & Longevity Medicine Master (University of Barcelona).